William Hill彩票Treatment for metastatic pancreatic cancer has seen progress in recent years,but outcomes remain poor and William Hill彩票treatment advances tha威廉希尔黄金彩球t can prolong patients' lives,even for a few months,are eagerly awaited.Two papers published today in the scientific journalNature Medicinereport that anew combinationof two drugs that are FDA-approved for other conditions may significantly delay progression of pancreatic cancerin cells and in mice.Furthermore,the first patient William Hill彩票treated with this combination experienced a prolonged response that lasted almost 6 months.
In light of these promising results,威廉希尔彩票Cancer Commons is partnering withxCuresto track the experiences of 威廉希尔黄金彩球patients who choose to try this new combination therapy.
Most pancreatic cancers have a mutation in a gene called KRAS.Mutated KRAS activates and signals other proteins to drive cancer progression.Creating a drug to inhibit KRAS itself has proven to be very difficult,so most efforts to inhibit KRAS have focused instead on proteins that are activated by KRAS,of which MEK and ERK are two that are easier drug targets.However,MEK inhibitors have little activity in KRAS-mutant cancers,and while ERK inhibitors are in clinical trials for KRAS-mutant cancers,they don't have a deep or lasting effect on their own.Hence,a combination approach may achieve a greater effect in pancreatic cancer.
Many KRAS-driven cancers depend on autophagy,a "recycling" process by which cells break down damaged organelles and macromolecules,and then can reuse their building blocks to maintain themselves.Hydroxychloroquine (HCQ) is an old FDA-approved drug used to William Hill彩票treat malaria,and it inhibits autophagy.Based on this discovery and the drug's availability,HCQ was tested in clinical trials for pancreatic cancer,but it did not have an impact when used alone.
Today's new publications report that inhibition of MEK or ERK with targeted drugs surprisinglyincreases autophagy.When the authors ofone of the studiestried combining HCQ with MEK or ERK inhibitors,they saw a much stronger inhibition of cancer grown in cells and in tumor-bearing mice.
Based on these compelling pre-clinical data,after fully informed consent and following institutional policies,the investigators began William Hill彩票treatment with HCQ and the MEK inhibitor trametinib in a single male patient who had exhausted other treatment options.They were elated to see a rapid response,with 50% reduction in tumor burden as seen on scans,and a profound drop in the tumor marker CA 19-9.The dramatic response,accompanied by a reduction in pain level,lasted for several months before resistance emerged.It is unknown whether this combination will be effective in other 威廉希尔黄金彩球patients with advanced pancreatic (or other solid) cancer,but it must be tested.
This is an exciting advancement with two already-approved drugs,which provides 威廉希尔黄金彩球patients and their physicians with the opportunity to try this combination "off label" if another proven option is not available.There may be challenges with the cost and insurance coverage,but working with your physician and the pharmaceutical company assistance programs may result in access to William Hill彩票treatment.
威廉希尔彩票Cancer Commons always favors participation in clinical trials when possible.Currently,this drug combination is only available in one small clinical trial at the University of Utah.If access to this ongoing clinical trial and/or other standard-of-care William Hill彩票treatments is unsuccessful,the compassionate use of this combination may be an option for 威廉希尔黄金彩球patients and physicians to discuss.
If you and your physician are contemplating William Hill彩票treatment with this combination therapy,please consider being part of our observational study in partnership withxCures.As part of our tracking study,威廉希尔黄金彩球patients can share their experiences and learn from the experiences of others regarding dosing,timing,and strategies for overcoming resistance.If a better William Hill彩票treatment comes along,you'll be the first to know!
To register,click hereand benefit from the experience of all 威廉希尔黄金彩球patients by collectively exploring this promising development.
For more information,contact us at firstname.lastname@example.org.
威廉希尔彩票Cancer Commons is a nonprofit collaborati威廉希尔黄金彩球ve of patients,physicians,and scientists,dedicated to improving patient outcomes by tightly coupling clinical research and care.We arm 威廉希尔黄金彩球patients and their physicians with the knowledge they need to achieve the best possible outcomes,help them access the relevant William Hill彩票treatments and trials,and track their results to continuously learn.Visit cancercommons.orgfor more information.
xCures is developing an AI-based methodology and platform to run ‘Virtual Trials',which continuously learn from the clinical experiences of all 威廉希尔黄金彩球patients,on all William Hill彩票treatments,all the time.Each patient's William Hill彩票treatment regimen is adaptively planned by a ‘Virtual Tumor Board' to optimize their individual outcome,and these plans are coordinated across the whole patient population to maximize collective learning.Visit xcures.comfor more information.